Study: Up to 98% of NFL Players May Have CTE

Is this a genuine crisis or are alarming statistics skewed by selection bias in brain donation research?
Study: Up to 98% of NFL Players May Have CTE
Above: The NFL shield logo on a ball. Image credit: Aaron M. Sprecher/Getty Images

The Facts

  • A study published Tuesday in the British Medical Journal found that at least 25% of former NFL players who died between 2016 and 2021 had chronic traumatic encephalopathy (CTE), with researchers estimating the maximum possible prevalence at 97.7%.
  • Of the 878 former NFL players who died during the study period, 235 donated their brains for research, and 215 — or 91.4% — were diagnosed with CTE, a degenerative brain disease that can only be confirmed after death.
  • The study, conducted by researchers from Mass General Brigham, Boston University and the Concussion & CTE Foundation, also found that more than 90% of brain donors with Stage IV CTE — the most advanced form — were also diagnosed with dementia.

Sources Split


The Spin


Narrative A

The NFL has a serious CTE problem and can't keep looking the other way. The estimates being made based on this latest study are conservative. Kids as young as 5 are still being taught to tackle, absorbing repeated head impacts that cause irreversible brain damage. That's simply unconscionable when flag football exists as a safer alternative.

Narrative B

These statistics are driven by severe selection bias. Brains donated for research almost exclusively come from families who already noticed something was wrong. Star quarterbacks from football's most brutal era are aging just fine, which the doom-and-gloom narrative can't explain. Even the researchers themselves admit the messaging has outpaced the actual evidence.

© 2026 Improve the News Foundation. All rights reserved.Version 7.18.3

© 2026 Improve the News Foundation.

All rights reserved.

Version 7.18.3