Study: Psilocybin Shows Potential Promise in Treating Cocaine Addiction

Is psilocybin a breakthrough for cocaine addiction or another psychedelic overhyped before the science is ready?
Study: Psilocybin Shows Potential Promise in Treating Cocaine Addiction
Above: Psilocybin mushrooms grow in a humidified monotub in Fairfield County, Conn., on Dec. 24, 2023. Image credit: John Moore/Getty Images

The Spin


Narrative A

Psilocybin just cracked open a door that's been locked for 40 years — no drug has ever worked for cocaine use disorder until now. A UAB clinical trial published in JAMA Network Open showed psilocybin recipients had 29% more cocaine-abstinent days, with 30% achieving complete abstinence compared to zero in the placebo group. This is a durable, confirmed result across a deliberately diverse, low-income population that's been ignored by research for too long.

Narrative B

Psychedelic research has a serious credibility problem that can't be papered over with promising headlines. The FDA already rejected MDMA-assisted therapy, and a systematic review found high bias risk across nearly all psychedelic addiction and mental health trials. Rushing psilocybin toward approval before fixing these foundational research flaws risks repeating the same mistakes and harming the very vulnerable people these treatments claim to help.


Metaculus Prediction

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All rights reserved.

Version 7.6.0